2, Statins (Atrovastatine, Simvastatine, Levostatine… etc). Cholesterol is needed for fetal growth and its reduction by statins could harm the fetus.
3, Warfarin:- Causes multiple birth defects.
4, Testosterone:- Can cause birth defects.
5, Misoprostol:- Miscarriage.
6, Sulfamethoxazole/trimethoprim (Bactrim) during 3rd trimester. May increase bilirubin levels leading to kernicterus.
7, Nitroimidazole, (Metronidazole and Tinidazole) during 1st trimester.
8, Griseofulvin:- May increased risk of spontaneous abortion.
9, Methotrexate:- Causes cleft palate along with multiple defects.
10, Estradiol:- Urogenital abnormalities in offspring that manifest later in life. May couse uterine cervix, vaginal and testicular cancer have developed later in life in offspring.
11, Thalidomide:- Seal like limbs and other defects.
12, Clomiphene citrate:- Can cause birth defects.
13, Medroxyprogesterone acetate:- Can cause birth defects.
14, Vitamin A and its derivatives:- Birth defects, miscarriage.
15, Danazol:- Causes malformations in sex organs of female fetus.
16, Finasteride:- Even pregnant women should not handle broken or crushed tablets since it can get absorbed through the skin and affect the sex organ development of the male fetus.
16, Tetracyclines:- Get deposited in fetal bones and retard their growth, also affect teeth causing them to be discolored and deformed.
17, Chloramphenicol:- Gray baby syndrome.
18, Isoniazid:- Neuropthy and seizures in fetus, liver damage in mother.
19, Sodium Valproate:- Defects of the nervous system.
20, ACE inhibitors (Enalapril, Captopril, Lisinopril…etc):- Growth retardation, birth defects, fetal death.
21, Lithium:- Affects fetal thyroid, heart beside causing other abnormalities.
22, Phenytoin:- Cleft lip/ palate along with other deformities.
23, Anti convulsants:- Trimethadione, Valproic acid, Carbamazepine – Multiple birth defects.
24, Androgens:- Multiple defects.
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